期刊
POLYMERS
卷 12, 期 12, 页码 -出版社
MDPI
DOI: 10.3390/polym12122936
关键词
proteins; silk; additive manufacturing; photo-initiators; tyrosine; free radicals
资金
- AFOSR [FA9550-17-1-0333]
- NIH [P41EB027062, R01EB021264, R01NS092847, U01EB014976]
- NSF [DMR-1608125]
Silk fibroin in material formats provides robust mechanical properties, and thus is a promising protein for 3D printing inks for a range of applications, including tissue engineering, bioelectronics, and bio-optics. Among the various crosslinking mechanisms, photo-crosslinking is particularly useful for 3D printing with silk fibroin inks due to the rapid kinetics, tunable crosslinking dynamics, light-assisted shape control, and the option to use visible light as a biocompatible processing condition. Multiple photo-crosslinking approaches have been applied to native or chemically modified silk fibroin, including photo-oxidation and free radical methacrylate polymerization. The molecular characteristics of silk fibroin, i.e., conformational polymorphism, provide a unique method for crosslinking and microfabrication via light. The molecular design features of silk fibroin inks and the exploitation of photo-crosslinking mechanisms suggest the exciting potential for meeting many biomedical needs in the future.
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