期刊
POLYMERS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/polym13020270
关键词
additive manufacturing; phosphate glass fiber; polylactic acid; gyroid; bone tissue engineering scaffold
The addition of MgO in composite materials of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) can neutralize the acidic degradation products, maintaining a neutral pH environment during degradation. The resulting (MgO + PGF)/PLA composite scaffold shows potential for bone tissue engineering applications.
Composites of biodegradable phosphate glass fiber and polylactic acid (PGF/PLA) show potential for bone tissue engineering scaffolds, due to their ability to release Ca, P, and Mg during degradation, thus promoting the bone repair. Nevertheless, glass degradation tends to acidify the surrounding aqueous environment, which may adversely affect the viability and bone-forming activities of osteoblasts. In this work, MgO was investigated as a neutralizing agent. Porous network-phase gyroid scaffolds were additive-manufactured using four different materials: PLA, MgO/PLA, PGF/PLA, and (MgO + PGF)/PLA. The addition of PGF enhanced compressive properties of scaffolds, and the resultant scaffolds were comparably strong and stiff with human trabecular bone. While the degradation of PGF/PLA composite induced considerable acidity in degradation media and intensified the degradation of PGF in return, the degradation media of (MgO + PGF)/PLA maintained a neutral pH close to a physiological environment. The experiment results indicated the possible mechanism of MgO as the neutralizing agent: the local acidity was buffered as the MgO reacted with the acidic degradation products thereby inhibiting the degradation of PGF from being intensified in an acidic environment. The (MgO + PGF)/PLA composite scaffold appears to be a candidate for bone tissue engineering.
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