期刊
PLOS PATHOGENS
卷 17, 期 1, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.ppat.1009220
关键词
-
资金
- AMED [JP19fk0210062]
- JSPS KAKENHI [JP17H05070]
- U.S. National Institutes of Health [R01-AI103083, R01-AI131685, R01-AI150095]
- National Natural Science Foundation of China [31772875]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA24030104]
IRF1, a key nuclear factor, not only activates interferon genes, but also regulates host defense against invading pathogens. Conserved in vertebrates, IRF1 plays an important role in combating viral infections.
The eponymous member of the interferon regulatory factor (IRF) family, IRF1, was originally identified as a nuclear factor that binds and activates the promoters of type I interferon genes. However, subsequent studies using genetic knockouts or RNAi-mediated depletion of IRF1 provide a much broader view, linking IRF1 to a wide range of functions in protection against invading pathogens. Conserved throughout vertebrate evolution, IRF1 has been shown in recent years to mediate constitutive as well as inducible host defenses against a variety of viruses. Fine-tuning of these ancient IRF1-mediated host defenses, and countering strategies by pathogens to disarm IRF1, play crucial roles in pathogenesis and determining the outcome of infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据