期刊
PEDIATRIC OBESITY
卷 16, 期 5, 页码 -出版社
WILEY
DOI: 10.1111/ijpo.12748
关键词
gut microbiota; insulin; Mexico; paediatric obesity; triglycerides
类别
资金
- Instituto Mexicano del Seguro Social [FIS/IMSS/PROT/PRIO/17/062]
The gut microbial community structure in children is associated with obesity, fasting plasma insulin (FPI) in Mexico City, and with obesity, FPI, and triglycerides (TG) in Oaxaca.
Background The association of gut microbiota with obesity and its cardio-metabolic complications in paediatric populations is still controversial. Objective We investigated the association of obesity and cardio-metabolic traits with gut microbiota on 167 and 163 children with normal weight and obesity from Mexico City and Oaxaca, Mexico. Methods Anthropometric and biochemical traits were measured. The microbial communities were determined by high-throughput sequencing of bacterial 16S rRNA gene v3-v4 region. Results The gut microbial community structure was associated with obesity and fasting plasma insulin (FPI) in Mexico City (P-Obesity = 0.012, P-FPI = 0.0003) and Oaxaca (P-Obesity = 0.034, P-FPI = 0.016), and with triglycerides (TG) in Oaxaca (P = .0002). The Firmicutes/Bacteroidetes ratio was positively associated with TG in Oaxaca (P = .003). Firmicutes and Bacteroidetes phyla were positively and negatively associated with obesity (Mexico City: P-Firmicutes = 0.013, P-Bacteroidetes = 0.009) and TG (Oaxaca: P-Firmicutes = 0.002, P-Bacteroidetes = 0.004). In Oaxaca, Verrucomicrobia was negatively associated with obesity (P = .004). In Mexico City, the bacterial genus Fusicatenibacter, Romboutsia, Ruminococcaceae, Ruminiclostridium, Blautia, Clostridium, Anaerostipes and Intestinibacter were associated with obesity and FPI, while in Oaxaca, Bacteroides, Alistipes and Clostridium were associated with TG. Conclusion The gut microbial community structure in children is associated with obesity and FPI in Mexico City, and with obesity, FPI and TG in Oaxaca.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据