The relationship between different C-peptide level and insulin dose of insulin pump

Background This study aims to explore the insulin requirement profiles, and analyze the related factors of type-2 diabetes mellitus (T2DM) with different C-peptide levels on insulin pump therapy. Methods A retrospective study was conducted on 271 T2DM patients treated with insulin pumps from 2016 to 2018. These patients were divided into groups according to the ratio of C-peptide at 2 h after meals to fasting C-peptide (C(2)h/C-0), and the dosage of insulin and influencing factors were analyzed. Results In comparing group A (C-2h/C-0 < 2.5) with group B (C-2h/C-0 >= 2.5), the percentage of the base amount in total (%TBa, 0.50 +/- 0.06) in group A was higher than that in group B (0.48 +/- 0.05) (P < 0.05). Furthermore, there was a correlation between C-2h/C-0 and waist circumference, HbA1c, Fasting Plasma Glucose (FPG) and Blood glucose 2 h after meal (2hPG) (r = -0.137, -0.154, -0.471, and -0.172; all, P < 0.05). The multiple linear regression analysis revealed that BMI and FPG were independent factors of %TBa (beta ' = 0.124 and 0.144; all, P < 0.05), and BMI and FPG were independent factors of C-2h/C-0 (beta ' = -0.134 and -0.502; all, P < 0.05). Conclusions The basal premeal dose ratio of T2DM with different C-peptide levels differs during intensive insulin pump therapy. Parameters that indicate the glycemic control and beta-cell function should be taken into consideration for total insulin requirements.

Automated summary

This study investigated the insulin requirement profiles of T2DM patients with different C-peptide levels on insulin pump therapy. It found differences in basal premeal dose ratio between groups, as well as correlations between C-2h/C-0 and waist circumference, HbA1c, FPG, and 2hPG. BMI and FPG were identified as independent factors influencing %TBa and C-2h/C-0.