期刊
NANO-MICRO LETTERS
卷 13, 期 1, 页码 -出版社
SHANGHAI JIAO TONG UNIV PRESS
DOI: 10.1007/s40820-020-00583-2
关键词
Plasmon enhancement; Photosensitizer; Aggregation-induced emission; Fluorescence imaging; Theranostics
资金
- Agency of Science, Technology and Research (A*STAR), Singapore
- Institute of Materials Research and Engineering [IMRE/00-1P1400]
- Newcastle University [RSA/CCEAMD5010]
- National University of Singapore [R279-000- 482-133]
- NRF Investigatorship [R279-000-444-281]
This study introduces a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots for image-guided photodynamic therapy. By carefully selecting AuNS with different localized surface plasmon peaks, the fluorescence and photosensitization of AIE-PS dots were significantly enhanced.
Dual-functional aggregation-induced photosensitizers (AIE-PSs) with singlet oxygen generation (SOG) ability and bright fluorescence in aggregated state have received much attention in image-guided photodynamic therapy (PDT). However, designing an AIE-PS with both high SOG and intense fluorescence via molecular design is still challenging. In this work, we report a new nanohybrid consisting of gold nanostar (AuNS) and AIE-PS dots with enhanced fluorescence and photosensitization for theranostic applications. The spectral overlap between the extinction of AuNS and fluorescence emission of AIE-PS dots (665 nm) is carefully selected using five different AuNSs with distinct localized surface plasmon (LSPR) peaks. Results show that all the AuNSs can enhance the O-1(2) production of AIE-PS dots, among which the AuNS with LSPR peak at 585 nm exhibited the highest O-1(2) enhancement factor of 15-fold with increased fluorescence brightness. To the best of our knowledge, this is the highest enhancement factor reported for the metal-enhanced singlet oxygen generation systems. The Au585@AIE-PS nanodots were applied for simultaneous fluorescence imaging and photodynamic ablation of HeLa cancer cells with strongly enhanced PDT efficiency in vitro. This study provides a better understanding of the metal-enhanced AIE-PS nanohybrid systems, opening up new avenue towards advanced image-guided PDT with greatly improved efficacy.
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