期刊
出版社
MDPI
DOI: 10.3390/ijerph18020511
关键词
NLRP3 inflammasome; metabolic stress; insulin resistance; diabetes; obesity
资金
- Deputyship for Research and Innovation, Ministry of Education in Saudi Arabia [IFKSURP2020-140]
NLRP3 inflammasome activation triggers inflammatory response, but improper activation may lead to autoimmune diseases, and is also associated with obesity and insulin resistance. Understanding the regulatory mechanisms of NLRP3 inflammasome in adipose tissue may help in the development of specific inhibitors for the treatment and prevention of metabolic diseases.
NLRP3 inflammasome is one of the multimeric protein complexes of the nucleotide-binding domain, leucine-rich repeat (NLR)-containing pyrin and HIN domain family (PYHIN). When activated, NLRP3 inflammasome triggers the release of pro-inflammatory interleukins (IL)-1 beta and IL-18, an essential step in innate immune response; however, defective checkpoints in inflammasome activation may lead to autoimmune, autoinflammatory, and metabolic disorders. Among the consequences of NLRP3 inflammasome activation is systemic chronic low-grade inflammation, a cardinal feature of obesity and insulin resistance. Understanding the mechanisms involved in the regulation of NLRP3 inflammasome in adipose tissue may help in the development of specific inhibitors for the treatment and prevention of obesity-mediated metabolic diseases. In this narrative review, the current understanding of NLRP3 inflammasome activation and regulation is highlighted, including its putative roles in adipose tissue dysfunction and insulin resistance. Specific inhibitors of NLRP3 inflammasome activation which can potentially be used to treat metabolic disorders are also discussed.
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