期刊
CELL REPORTS
卷 33, 期 10, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.108457
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- NASA [NNX14AH51G, NNX14AB01G, 80NSSC19K0434, NNX17AB26G]
- Human Health Countermeasures Element of the NASA Human Research Program
- NASA [NNX17AB26G, 1002384, NNX14AH51G, 683145] Funding Source: Federal RePORTER
Telomere length dynamics and DNA damage responses were assessed before, during, and after one-year or shorter duration missions aboard the International Space Station (ISS) in a comparatively large cohort of astronauts (n = 11). Although generally healthy individuals, astronauts tended to have significantly shorter telomeres and lower telomerase activity than age- and sex-matched ground controls before and after spaceflight. Although telomeres were longer during spaceflight irrespective of mission duration, telomere length shortened rapidly upon return to Earth, and overall astronauts had shorter telomeres after spaceflight than they did before; inter-individual differences were identified. During spaceflight, all crewmembers experienced oxidative stress, which positively correlated with telomere length dynamics. Significantly increased frequencies of chromosomal inversions were observed during and after spaceflight; changes in cell populations were also detected, We propose a telomeric adaptive response to chronic oxidative damage in extreme environments, whereby the telomerase-independent Alternative Lengthening of Telomeres (ALT) pathway is transiently activated in normal somatic cells.
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