Cancer Stemness Meets Immunity: From Mechanism to Therapy

Cancer stem cells (CSCs) are self-renewing cells that facilitate tumor initiation, promote metastasis, and enhance cancer therapy resistance. Transcriptomic analyses acrossmany cancer types have revealed a prominent association between stemness and immune signatures, potentially implying a biological interaction between such hallmark features of cancer. Emerging experimental evidence has substantiated the influence of CSCs on immune cells, including tumor-associated macrophages, myeloid-derived suppressor cells, and T cells, in the tumor microenvironment and, reciprocally, the importance of such immune cells in sustaining CSC stemness and its survival niche. This review covers the cellular and molecular mechanisms underlying the symbiotic interactions between CSCs and immune cells and how such heterotypic signaling maintains a tumor-promoting ecosystem and informs therapeutic strategies intercepting this co-dependency.

Automated summary

This review explores the symbiotic interactions between cancer stem cells and immune cells, highlighting the importance of tumor-associated macrophages, myeloid-derived suppressor cells, and T cells in maintaining CSC stemness and survival niche. It also discusses therapeutic strategies targeting this co-dependency to disrupt tumor-promoting ecosystems.