期刊
CANCER RESEARCH AND TREATMENT
卷 53, 期 3, 页码 784-794出版社
KOREAN CANCER ASSOCIATION
DOI: 10.4143/crt.2020.1064
关键词
Double tract reconstruction; Proximal gastrectomy; Reflux esophagitis; Quality of life
类别
资金
- Research Incubation Project, Beijing Municipal Administration of Hospitals [PX2019039]
The study compared the use of double tract reconstruction and esophagogastrostomy in radical proximal gastrectomy, showing that double tract reconstruction had better efficacy and improved patient quality of life. This was evidenced by lower rates of postoperative reflux esophagitis, better physical and emotional health status, and fewer discomfort symptoms.
Purpose The aim of the present study was to compare the difference between double tract reconstruction and esophagogastrostomy. Materials and Methods Patients who underwent radical proximal gastrectomy with esophagogastrostomy or double tract reconstruction were included in this study. Results Sixty-four patients were included in this study and divided into two groups according to reconstruction method. The two groups were well balanced in perioperative safety and 3-year overall survival (OS). The rates of postoperative reflux esophagitis in the double tract reconstruction group and esophagogastrostomy group were 8.0% and 30.8%, respectively (p=0.032). Patients in the double tract reconstruction group had a better global health status (p < 0.001) and emotional functioning (p < 0.001), and complained less about nausea and vomiting (p < 0.001), pain (p=0.039), insomnia (p=0.003), and appetite loss (p < 0.001) based on the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire. Regarding the EORTC QLQ-STO22 questionnaire, patients in the double tract reconstruction group complained less about dysphagia (p=0.030), pain (p=0.008), reflux (p < 0.001), eating (p < 0.001), anxiety (p < 0.001), dry mouth (p=0.007), and taste (p=0.001). The multiple linear regression analysis showed that reconstruction method, postoperative complications, reflux esophagitis, and operation duration had a linear relationship with the global health status score. Conclusion Double tract reconstruction could better prevent reflux esophagitis and improve quality of life without scarifying perioperative safety or 3-year OS.
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