期刊
ADVANCED HEALTHCARE MATERIALS
卷 10, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/adhm.202002171
关键词
cascade catalysis; Fenton reaction; glucose oxidase; immunotherapy
资金
- National Natural Science Foundation of China [81901878, 81874304]
- China Postdoctoral Science Foundation [2020T130611, 2019M662553]
- Key Scientific Research Projects Plan of Henan Higher Education Institutions [20A350011]
- Modern Analysis and Computer Center of Zhengzhou University
The cascade catalytic nanoplatform based on glucose oxidase modified mesoporous iron oxide nanoparticles loaded with Artemisinin utilizes the tumor microenvironment to carry out a series of reactions for cancer therapy, including tumor starvation therapy, oxidation reactions, and chemodynamic therapy, resulting in enhanced immunotherapy effects.
The unique tumor microenvironment (TME) characteristics such as immunosuppression impeded traditional cancer treatments. In contrast, developing cascade catalytic nanoplatforms by fully making use of substances in TME for cancer therapy may deserve full credit. Herein, a cascade catalytic nanoplatform based on glucose oxidase (GOD) modified mesoporous iron oxide nanoparticles (IONP) loaded with Artemisinin (ART) is developed, which is designed as IONP-GOD@ART. GOD can catalyze the oxidization of glucose into gluconic acid and H2O2, which not only realizes tumor starvation therapy, but also provides H2O2 for IONP mediated Fenton reaction. Simultaneously, mesoporous IONP releases Fe2+ and Fe3+ ions in acidic TME. On the one hand, iron ions undergo Fenton reaction to generate hydroxyl radicals for chemodynamic therapy. On the other hand, the endoperoxide bridge in ART is broken in presence of Fe2+ and further generates reactive oxygen species (ROS) to achieve therapeutic purpose. In this sense, IONP-GOD@ART manipulates TME characteristics and leads to butterfly effect, which brings out a large amount of ROS for eliciting immunogenic cell death, inducing M1-TAMs polarization, and further reprogramming immunosuppressive TME for enhanced immunotherapy. By this delicate design, the cascade catalytic nanoplatform of IONP-GOD@ART realizes potent cancer immunotherapy for tumor regression and metastasis prevention.
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