期刊
WORLD NEUROSURGERY
卷 148, 期 -, 页码 94-109出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.wneu.2021.01.059
关键词
Carbon fiber; Implants; Neoplasm metastasis; Polyether ether ketone; Spine; Surgery; Titanium alloy
Instrumentation in metastatic spine tumor surgery (MSTS) plays a crucial role in providing stability to the spinal column. Titanium, the current material of choice, poses challenges in radiotherapy planning due to artifacts it generates, while PEEK, an emerging alternative, offers minimal stress shielding but lacks bioactivity and rigidity. Surface modification and composite formation may improve the bioactivity and mechanical properties of PEEK implants. Despite difficulties in handling, PEEK and modified PEEK implants show promise for future development in MSTS.
Instrumentation during metastatic spine tumor surgery (MSTS) provides stability to the spinal column in patients with pathologic fracture or iatrogenic instability produced while undergoing extensive decompression. Titanium is the current implant material of choice in MSTS. However, it hinders radiotherapy planning and generates artifacts, with magnetic resonance imaging and computed tomography scans used for postoperative evaluation of tumor recurrence and/or complications. The high modulus of elasticity of titanium (110 GPa) results in stress shielding, which may lead to construct failure at the boneeimplant interface. Polyether ether ketone (PEEK), a thermoplastic polymer, is an emerging alternative to titanium for use in MSTS. The modulus of elasticity of PEEK (3.6 GPa) is close to that of cortical bone (17-21 GPa), resulting in minimal stress shielding. Its radiolucent and nonmetallic properties cause minimal interference with magnetic resonance imaging and computed tomography scans. PEEK also causes low-dose perturbation for radiotherapy planning. However, PEEK has reduced bioactivity with bone and lacks sufficient rigidity to be used as rods in MSTS. The reduced bioactivity of PEEK may be addressed by 1) surface modification (introducing porosity or bioactive coating with hydroxyapatite [HA] or titanium) and 2) forming composites with HA/titanium. The mechanical properties of PEEK may be improved by forming composites with HA or carbon fiber. Despite these modifications, all PEEK and PEEK-based implants are difficult to handle and contour intraoperatively. Our review provides a comprehensive overview of PEEK and modified PEEK implants, with a description of their properties and limitations, potentially serving as a basis for their future development and use in MSTS.
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