4.5 Article

Type I interferons are essential while type II interferon is dispensable for protection against St. Louis encephalitis virus infection in the mouse brain

期刊

VIRULENCE
卷 12, 期 1, 页码 244-259

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/21505594.2020.1869392

关键词

Neglected arbovirus; flavivirus; St. Louis encephalitis; interferons; mouse model

资金

  1. Brazilian funding agency CNPq
  2. Brazilian funding agency CAPES
  3. INCT Dengue
  4. FAPESP [2018/03917-6, 18/10990-1]

向作者/读者索取更多资源

The research found that type I and type II interferons have different roles in St. Louis encephalitis virus infection, with type I interferon being essential for controlling viral replication while type II interferon is not associated with protection in this model.
St. Louis encephalitis virus (SLEV) is a neglected mosquito-borne flavivirus that causes severe neurological disease in humans. SLEV replication in the central nervous system (CNS) induces the local production of interferons (IFNs), which are attributed to host protection. The antiviral response to SLEV infection in the CNS is not completely understood, which led us to characterize the roles of IFNs using mouse models of St. Louis encephalitis. We infected mice deficient in type I IFN receptor (ABR(-/-)) or deficient in Type II IFN (IFN gamma(-/-)) and assessed the contribution of each pathway to disease development. We found that type I and II IFNs play different roles in SLEV infection. Deficiency in type I IFN signaling was associated to an early and increased mortality, uncontrolled SLEV replication and impaired ISG expression, leading to increased proinflammatory cytokine production and brain pathology. Conversely, IFN gamma(-/-) mice were moderately resistant to SLEV infection. IFN gamma deficiency caused no changes to viral load or SLEV-induced encephalitis and did not change the expression of ISGs in the brain. We found that type I IFN is essential for the control of SLEV replication whereas type II IFN was not associated with protection in this model.

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