期刊
SCIENTIFIC REPORTS
卷 11, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41598-020-79748-3
关键词
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资金
- NIH [P41EB015902, R01MH074794, R01MH111917, R01MH119222, R01MH116173, R21MH115280, R21MH116352, K01MH117346]
The study introduces a new approach for analyzing diffusion MRI data using tensor-valued encoding technique, which can better characterize tissue microstructure. Novel imaging indices are derived to distinguish different ensembles of diffusion processes. The effectiveness of the proposed method is demonstrated using synthetic data and in vivo data from the human brain.
Probing the cellular structure of in vivo biological tissue is a fundamental problem in biomedical imaging and medical science. This work introduces an approach for analyzing diffusion magnetic resonance imaging data acquired by the novel tensor-valued encoding technique for characterizing tissue microstructure. Our approach first uses a signal model to estimate the variance and skewness of the distribution of apparent diffusion tensors modeling the underlying tissue. Then several novel imaging indices, such as weighted microscopic anisotropy and microscopic skewness, are derived to characterize different ensembles of diffusion processes that are indistinguishable by existing techniques. The contributions of this work also include a theoretical proof that shows that, to estimate the skewness of a diffusion tensor distribution, the encoding protocol needs to include full-rank tensor diffusion encoding. This proof provides a guideline for the application of this technique. The properties of the proposed indices are illustrated using both synthetic data and in vivo data acquired from a human brain.
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