4.7 Article

Mexican Ganoderma Lucidum Extracts Decrease Lipogenesis Modulating Transcriptional Metabolic Networks and Gut Microbiota in C57BL/6 Mice Fed with a High-Cholesterol Diet

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NUTRIENTS
卷 13, 期 1, 页码 -

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MDPI
DOI: 10.3390/nu13010038

关键词

hypercholesterolemia; Ganoderma lucidum; transcriptional profiles; lipid catabolism; microbiota

资金

  1. National Council of Science and Technology (CONACYT), Mexico [FORDECYT-273647]

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The study reveals that Ganoderma lucidum extracts modulate metabolic pathways related to lipid biosynthesis and degradation, with Gl-2 extract showing a major modulation over gene expression programs similar to simvastatin druggable-target-genes enriched in processes related to human obesity alterations in the liver. Additionally, certain Gl-modulated genes are correlated with Lactobacillus enrichment and the reduction of circulating cholesterol-derived fats. The extracts also induce a decrease in macrophage lipid storage, suggesting a new link between Gl's hypocholesterolemic and prebiotic activity in preventing metabolic disorders associated with hypercholesterolemia.
Prevention of hyperlipidemia and associated diseases is a health priority. Natural products, such as the medicinal mushroom Ganoderma lucidum (Gl), have demonstrated hypocholesterolemic, prebiotic and antidiabetic properties. However, the underlying transcriptomic mechanisms by which Gl exerts bioactivities are not completely understood. We report a comprehensive hepatic and renal transcriptome profiling of C57BL/6 mice under the consumption of a high-cholesterol diet and two standardized Gl extracts obtained from basidiocarps cultivated on conventional substrate (Gl-1) or substrate containing acetylsalicylic acid (ASA; Gl-2). We showed that Gl extracts modulate relevant metabolic pathways involving the restriction of lipid biosynthesis and the enrichment of lipid degradation and secretion. The Gl-2 extract exerts a major modulation over gene expression programs showing the highest similarity with simvastatin druggable-target-genes and these are enriched more in processes related to human obesity alterations in the liver. We further show a subset of Gl-modulated genes correlated with Lactobacillus enrichment and the reduction of circulating cholesterol-derived fats. Moreover, Gl extracts induce a significant decrease of macrophage lipid storage, which occurs concomitantly with the down-modulation of Fasn and Elovl6. Collectively, this evidence suggests a new link between Gl hypocholesterolemic and prebiotic activity, revealing thereby that standardized Mexican Gl extracts are a novel transcriptome modulator to prevent metabolic disorders associated with hypercholesterolemia.

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