期刊
NUTRIENTS
卷 13, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu13010258
关键词
tocotrienols; vitamin E; diabetic kidney disease; antifibrotic; antioxidant; anti-inflammatory; transforming growth factor-beta 1 (TGF-β 1)
资金
- Monash University Malaysia under the Tropical Medicine and Biology (TMB) grant [TMB-2018-CR3185140918-SuzTMQ/KAK]
- Fundamental Research Grant Scheme from the Malaysian Ministry of Higher Education [FRGS/1/2018/SKK02/MUSM/02/1]
The study evaluated the effects of tocotrienol-rich vitamin E supplementation on DKD patients over a 12-month period, showing significant improvements in renal function for patients with stage 3 CKD. The supplementation reduced serum creatinine levels and improved eGFR for these patients, indicating potential renoprotective effects of tocotrienols.
Diabetic kidney disease (DKD) is a debilitating complication of diabetes, which develops in 40% of the diabetic population and is responsible for up to 50% of end-stage renal disease (ESRD). Tocotrienols have shown to be a potent antioxidant, anti-inflammatory, and antifibrotic agent in animal and clinical studies. This study evaluated the effects of 400 mg tocotrienol-rich vitamin E supplementation daily on 59 DKD patients over a 12-month period. Patients with stage 3 chronic kidney disease (CKD) or positive urine microalbuminuria (urine to albumin creatinine ratio; UACR > 20-200 mg/mmol) were recruited into a randomized, double-blind, placebo-controlled trial. Patients were randomized into either intervention group (n = 31) which received tocotrienol-rich vitamin E (Tocovid SupraBio(TM); Hovid Berhad, Ipoh, Malaysia) 400 mg daily or a placebo group which received placebo capsules (n = 28) for 12 months. HbA1c, renal parameters (i.e., serum creatinine, eGFR, and UACR), and serum biomarkers were collected at intervals of two months. Tocovid supplementation significantly reduced serum creatinine levels (MD: -4.28 +/- 14.92 vs. 9.18 +/- 24.96), p = 0.029, and significantly improved eGFR (MD: 1.90 +/- 5.76 vs. -3.29 +/- 9.24), p = 0.011 after eight months. Subgroup analysis of 37 patients with stage 3 CKD demonstrated persistent renoprotective effects over 12 months; Tocovid improved eGFR (MD: 4.83 +/- 6.78 vs. -1.45 +/- 9.18), p = 0.022 and serum creatinine (MD: -7.85(20.75) vs. 0.84(26.03), p = 0.042) but not UACR. After six months post washout, there was no improvement in serum creatinine and eGFR. There were no significant changes in the serum biomarkers, TGF-beta 1 and VEGF-A. Our findings verified the results from the pilot phase study where tocotrienol-rich vitamin E supplementation at two and three months improved kidney function as assessed by serum creatinine and eGFR but not UACR.
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