期刊
NUTRIENTS
卷 13, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu13010210
关键词
magnesium transporters; digestive cancers; TCGA; overall survival
资金
- Ministere de l'Enseignement Superieur de la Recherche et de l'Innovation
- Universite de Picardie Jules Verne (UPJV)
- Universite de Lille
- le CHU Amiens-Picardie
- Institut National de la Sante et de la Recherche Medicale (Inserm)
- Centre National de la Recherche Scientifique (CNRS)
- La Ligue Nationale contre le Cancer (comite Septentrion)
- l'Agence Nationale de Securite Sanitaire, de l'Alimentation, de l'Environnement et du Travail
This study investigates the expression of Mg2+ transporters in digestive cancers and their impact on patient survival. The findings suggest that these Mg2+ transporters may affect various cancer cell characteristics and play a crucial role in regulating cancer cell fates and oncogenic signaling pathways.
Despite magnesium (Mg2+) representing the second most abundant cation in the cell, its role in cellular physiology and pathology is far from being elucidated. Mg2+ homeostasis is regulated by Mg2+ transporters including Mitochondrial RNA Splicing Protein 2 (MRS2), Transient Receptor Potential Cation Channel Subfamily M, Member 6/7 (TRPM6/7), Magnesium Transporter 1 (MAGT1), Solute Carrier Family 41 Member 1 (SCL41A1), and Cyclin and CBS Domain Divalent Metal Cation Transport Mediator (CNNM) proteins. Recent data show that Mg2+ transporters may regulate several cancer cell hallmarks. In this review, we describe the expression of Mg2+ transporters in digestive cancers, the most common and deadliest malignancies worldwide. Moreover, Mg2+ transporters' expression, correlation and impact on patient overall and disease-free survival is analyzed using Genotype Tissue Expression (GTEx) and The Cancer Genome Atlas (TCGA) datasets. Finally, we discuss the role of these Mg2+ transporters in the regulation of cancer cell fates and oncogenic signaling pathways.
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