期刊
MATERIALS
卷 14, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/ma14020439
关键词
lung mechanics; micro-CT; synchrotron; digital volume correlation; alveoli
类别
资金
- Royal Society [IEC\R3\170065]
- EPSRC [EP/M028267/1]
- European Regional Development Fund through the Welsh Government [80708]
- Welsh Government Enhancing Competitiveness Grant [MA/KW/5554/19]
- Diamond Light Source, Diamond-Manchester Branchline I13-2 [MT19348]
- EPSRC [EP/M028267/1] Funding Source: UKRI
The study established an experimental pipeline for capturing alveolar deformations during a respiratory cycle using synchrotron radiation micro-computed tomography. Regional differences in ventilation and non-uniform deformation behaviors were highlighted during the study. The technique presented can help characterize the multi-scale biomechanical nature of a given pathology to improve patient management strategies.
The mechanics of breathing is a fascinating and vital process. The lung has complexities and subtle heterogeneities in structure across length scales that influence mechanics and function. This study establishes an experimental pipeline for capturing alveolar deformations during a respiratory cycle using synchrotron radiation micro-computed tomography (SR-micro-CT). Rodent lungs were mechanically ventilated and imaged at various time points during the respiratory cycle. Pressure-Volume (P-V) characteristics were recorded to capture any changes in overall lung mechanical behaviour during the experiment. A sequence of tomograms was collected from the lungs within the intact thoracic cavity. Digital volume correlation (DVC) was used to compute the three-dimensional strain field at the alveolar level from the time sequence of reconstructed tomograms. Regional differences in ventilation were highlighted during the respiratory cycle, relating the local strains within the lung tissue to the global ventilation measurements. Strains locally reached approximately 150% compared to the averaged regional deformations of approximately 80-100%. Redistribution of air within the lungs was observed during cycling. Regions which were relatively poorly ventilated (low deformations compared to its neighbouring region) were deforming more uniformly at later stages of the experiment (consistent with its neighbouring region). Such heterogenous phenomena are common in everyday breathing. In pathological lungs, some of these non-uniformities in deformation behaviour can become exaggerated, leading to poor function or further damage. The technique presented can help characterize the multiscale biomechanical nature of a given pathology to improve patient management strategies, considering both the local and global lung mechanics.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据