期刊
MATERIALS
卷 13, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/ma13235321
关键词
ZnO nanorods; Raman spectroscopy; finite element method; optical diagnosis; label-free diagnosis; surface-enhanced Raman spectroscopy; local surface plasmon resonance
类别
资金
- National Research Foundation of Korea (NRF) [2019R1A6A3A01093658, 2019R1A2C2084122, 2020R1F1A1074033, 2020H1D3A1A02081127]
- MRC - Korean Ministry of Science ICT (MSIT) [2018R1A5A2020732]
- Korean Ministry of Trade, Industry and Energy under the Industrial Technology Innovation Program [10080726, 20000843]
- Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI18C2391]
- Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea [2017-621, 2017IL01740-1]
- Korea Evaluation Institute of Industrial Technology (KEIT) [10080726, 20000843] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2020R1F1A1074033, 2020H1D3A1A02081127, 2019R1A6A3A01093658] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Uniformly parallel Au-coated ZnO nanorods have previously been shown to amplify local Raman signals, providing increased sensitivity to disease markers in the detection of inflammation and cancer. However, practical and cost-effective fabrication methods of substrates for surface-enhanced Raman spectroscopy (SERS) fail to produce highly uniform surfaces. Here, the feasibility of Raman enhancement on less-uniform substrates is assessed. ZnO nanorod structures were fabricated by hydrothermal synthesis, starting from spin-coated seed substrates. Following analysis, the nanostructures were coated with Au to create stochastically variant substrates. The non-uniformity of the fabricated Au-coated ZnO nanorod structures is confirmed morphologically by FE-SEM and structurally by X-ray diffraction, and characterized by the angular distributions of the nanorods. Monte Carlo finite element method simulations matching the measured angular distributions and separations predicted only moderate increases in the overall Raman enhancement with increasing uniformity. Highly variant substrates exhibited approximately 76% of the Raman enhancement of more uniform substrates in simulations and experiments. The findings suggest that, although highly inhomogeneous Au-coated ZnO nanorod substrates may not attain the same Raman enhancement as more uniform substrates, the relaxation of fabrication tolerances may be economically viable.
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