期刊
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
卷 12, 期 6, 页码 865-869出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S2040174420001282
关键词
Delta(9)-THC; developmental toxicology; reproductive health; ovarian function; follicular angiogenesis
资金
- CIHR Project [PJT-155981]
- HSFC [G-19-0,026,343]
- Mexican National Council of Science and Technology (CONACYT)
Research shows that prenatal exposure to Delta(9)-THC affects ovarian health in adult rat offspring, leading to abnormal follicular development and decreased blood vessel density, highlighting the potential long-term impact of this component on female reproductive health.
With the legalization of marijuana (Cannabis sativa) and increasing use during pregnancy, it is important to understand its impact on exposed offspring. Specifically, the effects of Delta-9-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive component of cannabis, on fetal ovarian development and long-term reproductive health are not fully understood. The aim of this study was to assess the effect of prenatal exposure to Delta(9)-THC on ovarian health in adult rat offspring. At 6 months of age, Delta(9)-THC-exposed offspring had accelerated folliculogenesis with apparent follicular development arrest, but no persistent effects on circulating steroid levels. Ovaries from Delta(9)-THC-exposed offspring had reduced blood vessel density in association with decreased expression of the pro-angiogenic factor VEGF and its receptor VEGFR-2, as well as an increase in the anti-angiogenic factor thrombospondin 1 (TSP-1). Collectively, these data suggest that exposure to Delta(9)-THC during pregnancy alters follicular dynamics during postnatal life, which may have long-lasting detrimental effects on female reproductive health.
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