期刊
BLOOD CANCER JOURNAL
卷 11, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41408-020-00390-3
关键词
-
资金
- Projekt DEAL
In patients with multiple myeloma post autologous stem cell transplantation, maintenance treatment with bortezomib and lenalidomide showed no significant difference in progression-free survival and overall survival.
Lenalidomide (LEN) maintenance (MT) post autologous stem cell transplantation (ASCT) is standard of care in newly diagnosed multiple myeloma (MM) but has not been compared to other agents in clinical trials. We retrospectively compared bortezomib (BTZ; n=138) or LEN (n=183) MT from two subsequent GMMG phase III trials. All patients received three cycles of BTZ-based triplet induction and post-ASCT MT. BTZ MT (1.3mg/m(2) i.v.) was administered every 2 weeks for 2 years. LEN MT included two consolidation cycles (25mg p.o., days 1-21 of 28 day cycles) followed by 10-15mg/day for 2 years. The BTZ cohort more frequently received tandem ASCT (91% vs. 33%) due to different tandem ASCT strategies. In the LEN and BTZ cohort, 43% and 46% of patients completed 2 years of MT as intended (p=0.57). Progression-free survival (PFS; HR=0.83, p=0.18) and overall survival (OS; HR=0.70, p=0.15) did not differ significantly with LEN vs. BTZ MT. Patients with
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据