期刊
ARABIAN JOURNAL OF CHEMISTRY
卷 14, 期 3, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.arabjc.2021.102998
关键词
Coordination complexes; Luminescence; Liver cancer
资金
- National Natural Science Foundation of China [81360338]
- Key projects of Jiangxi science and Technology Department [20192BBG70036]
In this study, two new coordination polymers were successfully prepared using a mixed-ligand method. One of the polymers exhibited strong blue luminescence, which could be selectively quenched by Fe3+ ions. The compounds showed inhibitory effects on the viability of HepG2 liver cancer cells and affected the relative expression of prolyl hydroxylase-3.
In the current study, via utilizing a mixed-ligand method, two new coordination polymers (CPs) of {[Zn-5(pmbcd)(2)(mu(3)-OH)(2)(H2O)(4)(DMF)(2)]center dot 4DMF}(n) (1) and {[Zn-2(pmbcd)(bpea)(2)]center dot 2H(2)O center dot 2DMF}(n) (2) (in which bpea = 1,2-bis(4-pyridyl)ethane and H(4)pmbcd = 9,9'-(1,4-phenylene bis(methylene))bis(9H-carbazole-3,6-dicarboxylic acid)) have been successfully prepared using a tetracarboxylate ligand H(4)pmbcd without or with the present of the second co-ligand bpea. Furthermore, in the water, the complex 1 containing Zn5 clusters exhibits the strong blue luminescence, which can only be selectively quenched via the contaminant Fe3+ ion. For the treatment of liver cancer, the Cell Counting Kit-8 assay was implemented for the assessment of the compounds' inhibition on the HepG2 liver cancer cells viability. Moreover, the prolyl hydroxylase-3 relative expression in HepG2 liver cancer cells was also detected by the real time reverse transcription polymerase chain reaction. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of King Saud University.
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