Metal-Catalyzed Asymmetric Hydrogenation of C=N Bonds

This Review recaps the achievements in the field of metal-catalyzed asymmetric direct hydrogenation of nonactivated and activated imines. A summary of the reported catalytic systems with the corresponding reactivity, selectivity, and limitations is given including a discussion about the effects of some reaction conditions on the enantioselectivity of imine hydrogenation. An analysis of proposed imine hydrogenation mechanisms is discussed.

Automated summary

This review summarizes the achievements in the field of metal-catalyzed asymmetric direct hydrogenation of nonactivated and activated imines. It provides a summary of reported catalytic systems with their reactivity, selectivity, limitations, and discusses the effects of certain reaction conditions on the enantioselectivity of imine hydrogenation, as well as analysis of proposed imine hydrogenation mechanisms.