4.8 Article

No evidence for increased transmissibility from recurrent mutations in SARS-CoV-2

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Summary: Large-scale re-engineering of synonymous sites in generating vaccines involves strategies such as codon deoptimization and maximizing CpG dinucleotide frequencies. Analysis of SARS-CoV-2 genome sequences reveals biased mutation towards U nucleotides and systematic differences in CpG content, providing insights for vaccine development.

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