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Karl Grenier et al.
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Madel Durens et al.
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Roy Lardenoije et al.
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Bryan D. James et al.
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Jong-Chan Park et al.
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Emma Nichols et al.
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Yannis Gerakis et al.
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Reliability of human cortical organoid generation
Se-Jin Yoon et al.
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Abraam M. Yakoub et al.
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E. Schmukler et al.
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Florent Ginhoux et al.
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Yuan-Ta Lin et al.
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Harald Hampel et al.
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Jan Christoph Koch et al.
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Hayato Fukusumi et al.
PEERJ (2018)
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Cesar Gonzalez et al.
MOLECULAR PSYCHIATRY (2018)
BioLQM: A Java Toolkit for the Manipulation and Conversion of Logical Qualitative Models of Biological Networks
Aurelien Naldi
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Annexin A1 restores Aβ1-42-induced blood-brain barrier disruption through the inhibition of RhoA-ROCK signaling pathway
Jong-Chan Park et al.
AGING CELL (2017)
Neural organoids for disease phenotyping, drug screening and developmental biology studies
Brigham J. Hartley et al.
NEUROCHEMISTRY INTERNATIONAL (2017)
Korean Brain Aging Study for the Early Diagnosis and Prediction of Alzheimer's Disease: Methodology and Baseline Sample Characteristics
Min Soo Byun et al.
PSYCHIATRY INVESTIGATION (2017)
ApoE, ApoE Receptors, and the Synapse in Alzheimer's Disease
Courtney Lane-Donovan et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)
Chemically treated plasma Aβ is a potential blood-based biomarker for screening cerebral amyloid deposition
Jong-Chan Park et al.
ALZHEIMERS RESEARCH & THERAPY (2017)
Drug Discovery Testing Compounds in Patient Samples by Automated Flow Cytometry
Pilar Hernandez et al.
SLAS TECHNOLOGY (2017)
ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Aβ Secretion
Yu-Wen Alvin Huang et al.
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Wenrui Hao et al.
BMC SYSTEMS BIOLOGY (2016)
Enrichr: a comprehensive gene set enrichment analysis web server 2016 update
Maxim V. Kuleshov et al.
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Logical Modeling and Dynamical Analysis of Cellular Networks
Wassim Abou-Jaoude et al.
FRONTIERS IN GENETICS (2016)
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Waseem K. Raja et al.
PLOS ONE (2016)
Alzheimer's Disease Risk Genes and Mechanisms of Disease Pathogenesis
Celeste M. Karch et al.
BIOLOGICAL PSYCHIATRY (2015)
Functional cortical neurons and astrocytes from human pluripotent stem cells in 3D culture
Anca M. Pasca et al.
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Neelroop N. Parikshak et al.
NATURE REVIEWS GENETICS (2015)
Synaptic Therapy in Alzheimer's Disease: A CREB-centric Approach
Andrew F. Teich et al.
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The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
David Heras-Sandoval et al.
CELLULAR SIGNALLING (2014)
The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons
Christina R. Muratore et al.
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Clusterin regulates beta-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway
R. Killick et al.
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A three-dimensional human neural cell culture model of Alzheimer's disease
Se Hoon Choi et al.
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Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease
Stephen Salloway et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease
Rachelle S. Doody et al.
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The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes
Sung-Young Shin et al.
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George S. Bloom
JAMA NEUROLOGY (2014)
Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool
Edward Y. Chen et al.
BMC BIOINFORMATICS (2013)
SBML qualitative models: a model representation format and infrastructure to foster interactions between qualitative modelling formalisms and tools
Claudine Chaouiya et al.
BMC SYSTEMS BIOLOGY (2013)
Cerebral organoids model human brain development and microcephaly
Madeline A. Lancaster et al.
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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Chia-Chan Liu et al.
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Dysfunction of the mTOR pathway is a risk factor for Alzheimer’s disease
Sharon C Yates et al.
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The molecular and mathematical basis of Waddington's epigenetic landscape: A framework for post-Darwinian biology?
Sui Huang
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AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease
Satoshi Mizuno et al.
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Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells
Mason A. Israel et al.
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Neurogenesis in Alzheimer's disease
Jose J. Rodriguez et al.
JOURNAL OF ANATOMY (2011)
Calcium Signalling and Alzheimer's Disease
Michael J. Berridge
NEUROCHEMICAL RESEARCH (2011)
Reduction of Complex Signaling Networks to a Representative Kernel
Jeong-Rae Kim et al.
SCIENCE SIGNALING (2011)
DEGseq: an R package for identifying differentially expressed genes from RNA-seq data
Likun Wang et al.
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BoolNet-an R package for generation, reconstruction and analysis of Boolean networks
Christoph Muessel et al.
BIOINFORMATICS (2010)
Modelling Spatially Regulated β-Catenin Dynamics and Invasion in Intestinal Crypts
Philip J. Murray et al.
BIOPHYSICAL JOURNAL (2010)
MECHANISMS OF DISEASE Alzheimer's Disease
Henry W. Querfurth et al.
NEW ENGLAND JOURNAL OF MEDICINE (2010)
Modelling the dynamics of signalling pathways
Sree N. Sreenath et al.
ESSAYS IN BIOCHEMISTRY: SYSTEMS BIOLOGY, VOL 45 (2008)
Transcriptome-wide noise controls lineage choice in mammalian progenitor cells
Hannah H. Chang et al.
NATURE (2008)
Emergent decision-making in biological signal transduction networks
Tomas Helikar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Boolean dynamics of biological networks with multiple coupled feedback loops
Yung-Keun Kwon et al.
BIOPHYSICAL JOURNAL (2007)
The multi-step phosphorelay mechanism of unorthodox two-component systems in E. coli realizes ultrasensitivity to stimuli while maintaining robustness to noises
Jeong-Rae Kim et al.
COMPUTATIONAL BIOLOGY AND CHEMISTRY (2006)
Switching feedback mechanisms realize the dual role of MCIP in the regulation of calcineurin activity
Sung-Young Shin et al.
FEBS LETTERS (2006)
Amyloid excess in Alzheimer's disease: What is cholesterol to be blamed for?
Maria Dolores Ledesma et al.
FEBS LETTERS (2006)
Inhibition of the canonical Wnt signaling pathway by apolipoprotein E4 in PC12 cells
Alessandra Caruso et al.
JOURNAL OF NEUROCHEMISTRY (2006)
The influence of the signal dynamics of activated form of IKK on NF-κB and anti-apoptotic gene expressions:: A systems biology approach
SG Park et al.
FEBS LETTERS (2006)
Identification of small scale biochemical networks based on general type system perturbations
H Schmidt et al.
FEBS JOURNAL (2005)
Cell fates as high-dimensional attractor states of a complex gene regulatory network
S Huang et al.
PHYSICAL REVIEW LETTERS (2005)
KEGG: Kyoto Encyclopedia of Genes and Genomes
M Kanehisa et al.
NUCLEIC ACIDS RESEARCH (2000)