期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-20581-7
关键词
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资金
- Swiss National Science Foundation
- Swiss Neurological Society
- European Academy of Neurology
- EMDO Foundation fellowship
- CT Institute
- US NSF CAREER Award [1845348]
- Wellcome Trust MRC strategic neurodegenerative disease initiative award
- Dystonia Coalition
- Parkinson's UK [G-1009]
- EPSRC [EP/N014529/1]
- NIH [R01MH117063]
- HHMI
- DARPA [D20AC00004]
- UK Dementia Research Institute (UK DRI)-an initiative - Medical Research Council
- Alzheimer's Society
- Alzheimer's Research UK
- Wellcome Trust fellowship [097443/Z/ 11/Z]
- Science & PINS Award for Neuromodulation
- NIHR IBRC Confident in Concept Award
- [WT089698]
- MRC [UKDRI-5005] Funding Source: UKRI
- Wellcome Trust [097443/Z/11/Z] Funding Source: Wellcome Trust
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1845348] Funding Source: National Science Foundation
The study introduces a new method for real-time tracking of neural oscillations, which can be used to suppress aberrant neural oscillations associated with specific disorders, offering a new approach for the treatment of brain disorders.
Aberrant neural oscillations hallmark numerous brain disorders. Here, we first report a method to track the phase of neural oscillations in real-time via endpoint-corrected Hilbert transform (ecHT) that mitigates the characteristic Gibbs distortion. We then used ecHT to show that the aberrant neural oscillation that hallmarks essential tremor (ET) syndrome, the most common adult movement disorder, can be transiently suppressed via transcranial electrical stimulation of the cerebellum phase-locked to the tremor. The tremor suppression is sustained shortly after the end of the stimulation and can be phenomenologically predicted. Finally, we use feature-based statistical-learning and neurophysiological-modelling to show that the suppression of ET is mechanistically attributed to a disruption of the temporal coherence of the aberrant oscillations in the olivocerebellar loop, thus establishing its causal role. The suppression of aberrant neural oscillation via phase-locked driven disruption of temporal coherence may in the future represent a powerful neuromodulatory strategy to treat brain disorders. Aberrant synchronous oscillations have been associated with numerous brain disorders, including essential tremor. The authors show that synchronous cerebellar activity can casually affect essential tremor and that its underlying mechanism may be related to the temporal coherence of the tremulous movement.
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