期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-19741-6
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资金
- Crick African Network, African Career Accelerator Award [CANB0001/01]
- Centre of Excellence (Centre for Adolescent Rheumatology Versus Arthritis) [21593]
- Medical Research Council [MR/R013926/1]
- Great Ormond Street Children's Charity
- NIHR Biomedical Research Centre at University College London Hospital [BRC/III 525]
- Medical Research Foundation Lupus Fellowship [MRF-057-0001-RG-ROSS-C0797]
- NIHR Biomedical Research Centre at Great Ormond Street Hospital
- Versus Arthritis Studentship [22203]
- MRC [MR/P028071/1] Funding Source: UKRI
Anecdotal evidence suggests that Coronavirus disease 2019 (COVID-19), caused by the coronavirus SARS-CoV-2, exhibits differences in morbidity and mortality between sexes. Here, we present a meta-analysis of 3,111,714 reported global cases to demonstrate that, whilst there is no difference in the proportion of males and females with confirmed COVID-19, male patients have almost three times the odds of requiring intensive treatment unit (ITU) admission (OR=2.84; 95% CI=2.06, 3.92) and higher odds of death (OR=1.39; 95% CI=1.31, 1.47) compared to females. With few exceptions, the sex bias observed in COVID-19 is a worldwide phenomenon. An appreciation of how sex is influencing COVID-19 outcomes will have important implications for clinical management and mitigation strategies for this disease.
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