相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer
Timothy R. Baffi et al.
MOLECULAR CELL (2019)
Comprehensive profiling of the STE20 kinase family defines features essential for selective substrate targeting and signaling output
Chad J. Miller et al.
PLOS BIOLOGY (2019)
Common Regulatory Pathways Mediate Activity of MicroRNAs Inducing Cardiomyocyte Proliferation
Consuelo Torrini et al.
CELL REPORTS (2019)
The role of PTB domain containing adaptor proteins on PICALM-mediated APP endocytosis and localization
Lisa Merthan et al.
BIOCHEMICAL JOURNAL (2019)
Biophysical basis underlying dynamic Lck activation visualized by ZapLck FRET biosensor
Rongxue Wan et al.
SCIENCE ADVANCES (2019)
Architecture of human Rag GTPase heterodimers and their complex with mTORC1
Madhanagopal Anandapadamanaban et al.
SCIENCE (2019)
Structural basis for the docking of mTORC1 on the lysosomal surface
Kacper B. Rogala et al.
SCIENCE (2019)
mTOR as a central hub of nutrient signalling and cell growth
Joungmok Kim et al.
NATURE CELL BIOLOGY (2019)
AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA
Terri Clister et al.
CELL CHEMICAL BIOLOGY (2019)
Protein kinase Cα gain-of-function variant in Alzheimer's disease displays enhanced catalysis by a mechanism that evades down-regulation
Julia A. Callender et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
Nuclear/Cytoplasmic Fractionation of Proteins from Caenorhabditis elegans
Alejandro Mata-Cabana et al.
BIO-PROTOCOL (2018)
Aging Triggers Cytoplasmic Depletion and Nuclear Translocation of the E3 Ligase Mahogunin: A Function for Ubiquitin in Neuronal Survival
Stefano Benvegnu et al.
MOLECULAR CELL (2017)
mTORC1 Phosphorylates Acetyltransferase p300 to Regulate Autophagy and Lipogenesis
Wei Wan et al.
MOLECULAR CELL (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
Frequency modulation of ERK activation dynamics rewires cell fate
Hyunryul Ryu et al.
MOLECULAR SYSTEMS BIOLOGY (2015)
On the lag phase in amyloid fibril formation
Paolo Arosio et al.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS (2015)
Regulation of mTORC1 by PI3K signaling
Christian C. Dibble et al.
TRENDS IN CELL BIOLOGY (2015)
Compartmentalized AMPK Signaling Illuminated by Genetically Encoded Molecular Sensors and Actuators
Takafumi Miyamoto et al.
CELL REPORTS (2015)
Dynamic Visualization of mTORC1 Activity in Living Cells
Xin Zhou et al.
CELL REPORTS (2015)
Attenuation of AMPK signaling by ROQUIN promotes T follicular helper cell formation
Roybel R. Ramiscal et al.
ELIFE (2015)
Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway
J. J. Havel et al.
ONCOGENE (2015)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Suchithra Menon et al.
CELL (2014)
Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2
Constantinos Demetriades et al.
CELL (2014)
The nuclear import of ribosomal proteins is regulated by mTOR
Dubek Kazyken et al.
ONCOTARGET (2014)
Where is mTOR and what is it doing there?
Charles Betz et al.
JOURNAL OF CELL BIOLOGY (2013)
Regulation of mTORC1 and its impact on gene expression at a glance
Mathieu Laplante et al.
JOURNAL OF CELL SCIENCE (2013)
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
Christian C. Dibble et al.
NATURE CELL BIOLOGY (2013)
A Novel Quantitative Kinase Assay Using Bacterial Surface Display and Flow Cytometry
Sonia Troeira Henriques et al.
PLOS ONE (2013)
Nutrient signaling to mTOR and cell growth
Jenna L. Jewell et al.
TRENDS IN BIOCHEMICAL SCIENCES (2013)
Ivermectin is a specific inhibitor of importin α/β-mediated nuclear import able to inhibit replication of HIV-1 and dengue virus
Kylie M. Wagstaff et al.
BIOCHEMICAL JOURNAL (2012)
Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP
Vedangi Sample et al.
NATURE CHEMICAL BIOLOGY (2012)
Importazole, a Small Molecule Inhibitor of the Transport Receptor Importin-β
Jonathan F. Soderholm et al.
ACS CHEMICAL BIOLOGY (2011)
mTOR protein localization is cell cycle regulated
Margit Rosner et al.
CELL CYCLE (2011)
Visualization of PKA activity in plasma membrane microdomains
Charlene Depry et al.
MOLECULAR BIOSYSTEMS (2011)
PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains
Xinxin Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase
Roberto Zoncu et al.
SCIENCE (2011)
mTOR binds to the promoters of RNA polymerase I- and III-transcribed genes
Chi Kwan Tsang et al.
CELL CYCLE (2010)
Requirement of the mTOR Kinase for the Regulation of Maf1 Phosphorylation and Control of RNA Polymerase III-dependent Transcription in Cancer Cells
Boris Shor et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Regulation of Adipocyte Differentiation by Distinct Subcellular Pools of Protein Kinase B (PKB/Akt)
Tamara Maiuri et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1
Theodoros Kantidakis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
Jeremy Copp et al.
CANCER RESEARCH (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Carson C. Thoreen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1
Margit Rosner et al.
HUMAN MOLECULAR GENETICS (2008)
Integration of protein kinases mTOR and extracellular signal-regulated kinase 5 in regulating nucleocytoplasmic localization of NFATc4
Teddy T. C. Yang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport
Sang-Oh Yoon et al.
MOLECULAR CELL (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation
Bharath Ananthanarayanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
mTOR controls mitochondrial oxidative function through a YY1-PGC-1α transcriptional complex
John T. Cunningham et al.
NATURE (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Targeting protein kinase C activity reporter to discrete intracellular regions reveals spatiotemporal differences in agonist-dependent signaling
Lisa L. Gallegos et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
PML inhibits HIF-1α translation and neoangiogenesis through repression of mTOR
Rosa Bernardi et al.
NATURE (2006)
Rapamycin analogs with differential binding specificity permit orthogonal control of protein activity
JH Bayle et al.
CHEMISTRY & BIOLOGY (2006)
CellProfiler: image analysis software for identifying and quantifying cell phenotypes
Anne E. Carpenter et al.
GENOME BIOLOGY (2006)
Structure of S6 kinase 1 determines whether raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
SM Ali et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Gi protein activation in intact cells involves subunit rearrangement rather than dissociation
M Bünemann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function
SS Schaim et al.
CURRENT BIOLOGY (2003)
The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif
H Nojima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
DH Kim et al.
MOLECULAR CELL (2003)
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
KS Kovacina et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
K Inoki et al.
NATURE CELL BIOLOGY (2002)
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
K Hara et al.
CELL (2002)
MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
DH Kim et al.
CELL (2002)