期刊
NATURE COMMUNICATIONS
卷 11, 期 1, 页码 -出版社
NATURE RESEARCH
DOI: 10.1038/s41467-020-19671-3
关键词
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资金
- Strategic Priority Research Program of the Chinese Academy of Sciences (CAS) [XDB29010102]
- National Science and Technology Major Project [2018ZX10101004, 2018ZX10201001, 2018ZX10733403, 2020ZX10001-016]
- Second Tibetan Plateau Scientific Expedition and Research Program (STEP) [2019QZKK0304]
- National Key Research and Development Project of China [2016YFE0205800]
- National Natural Science Foundation of China (NSFC) [31870163, 32061123001]
- Shenzhen Science and Technology Research and Development Project [JCYJ20180504165549581]
- RFBR Research Project [19-54-55004]
- Earmarked Fund for Modern Agro-industry Technology Research System From Ministry of Agriculture of P. R. China [CARS-42]
- Cooperative Innovation Project (The Shanghai Cooperation Organization Science and Technology Partnership Program) [2017E01022]
- China-U.S. Collaborative Program on Emerging and Re-emerging Infectious Diseases [5U01IP001106-01]
- Academic Promotion Programme of Shandong First Medical University [2019QL006, 2019PT008]
- Taishan Scholars program of Shandong Province [ts201511056]
- NSFC Outstanding Young Scholars [31822055]
- Youth Innovation Promotion Association of CAS [2017122]
We have surveyed avian influenza virus (AIV) genomes from live poultry markets within China since 2014. Here we present a total of 16,091 samples that were collected from May 2016 to February 2019 in 23 provinces and municipalities in China. We identify 2048 AIV-positive samples and perform next generation sequencing. AIV-positive rates (12.73%) from samples had decreased substantially since 2016, compared to that during 2014-2016 (26.90%). Additionally, H9N2 has replaced H5N6 and H7N9 as the dominant AIV subtype in both chickens and ducks. Notably, novel reassortants and variants continually emerged and disseminated in avian populations, including H7N3, H9N9, H9N6 and H5N6 variants. Importantly, almost all of the H9 AIVs and many H7N9 and H6N2 strains prefer human-type receptors, posing an increased risk for human infections. In summary, our nation-wide surveillance highlights substantial changes in the circulation of AIVs since 2016, which greatly impacts the prevention and control of AIVs in China and worldwide. In this study, the authors present a genomic surveillance of avian influenza genomes sampled from live poultry markets in China. They report that a number of variants have emerged since 2016 that pose an increased risk to humans. They highlight the importance of continuous genome surveillance of circulating influenza strains.
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