期刊
NATURE COMMUNICATIONS
卷 12, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41467-020-20566-6
关键词
-
资金
- National Key R&D Program of China [2016YFA0203700]
- National Natural Science Foundation of China [51722211, 51672303, 51902336]
- Program of Shanghai Subject Chief Scientist [18XD1404300]
- Development Fund for Shanghai Talents [2018114]
- China Postdoctoral Science Foundation [2018M642097]
- Singapore National Research Foundation Investigatorship [NRF-NRFI2018-03]
- Singapore Academic Research Fund [TR12/19]
Development of organic theranostic agents active in the second near-infrared (NIR-II) region is crucial for treating deep-seated tumors. Boron difluoride formazanate nanosystem developed by the authors shows promising results in treating deep-seated hepatocellular carcinoma in mice using photonic hyperthermia.
Development of organic theranostic agents that are active in the second near-infrared (NIR-II, 1000-1700 nm) biowindow is of vital significance for treating deep-seated tumors. However, studies on organic NIR-II absorbing agents for photo-to-heat energy-converting theranostics are still rare simply because of tedious synthetic routes to construct extended systems in the NIR-II region. Herein, we design a convenient strategy to engineer highly stable organic NIR-II absorbing theranostic nanoparticles (Nano-BFF) for effective phototheranostic applications via co-assembling first NIR (NIR-I, 650-1000nm) absorbing boron difluoride formazanate (BFF) dye with a biocompatible polymer, endowing the Nano-BFF with remarkable theranostic performance in the NIR-II region. In vitro and in vivo investigations validate that Nano-BFF can serve as an efficient theranostic agent to achieve photoacoustic imaging guided deep-tissue photonic hyperthermia in the NIR-II biowindow, achieving dramatic inhibition toward orthotopic hepatocellular carcinoma. This work thus provides an insight into the exploration of versatile organic NIR-II absorbing nanoparticles toward future practical applications.Organic agents with activity in the second near infrared region (NIR-II) are needed for precise treatment of cancer. Here, the authors develop boron difluoride formazanate nanosystem as a theranostic agent active in the NIR-II region for treating deep-seated hepatocellular carcinoma in mice.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据