期刊
EXPERIMENTAL AND THERAPEUTIC MEDICINE
卷 21, 期 1, 页码 -出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/etm.2020.9475
关键词
miRNA-30b; tumor; cardiovascular diseases; metabolism; biomarker
资金
- National Natural Science Foundation of China [31770837]
miR-30b, a 21-23 nucleotide long non-coding RNA, has been shown to inhibit cell proliferation, migration, invasion and epithelial-mesenchymal transformation in various types of cancer, as well as play essential roles in cardiovascular and metabolic diseases. It is considered a potential candidate for clinical development as a diagnostic and prognostic biomarker, therapeutic agent and drug target, although further research is needed to fully understand its role in health and disease.
MicroRNAs (miRNAs) are non-coding RNAs 21-23 nucleotides in length that regulate gene expression, and thereby modulate signaling pathways and protein synthesis in both physiological and pathogenic processes. miR-30b inhibits cell proliferation, migration, invasion and epithelial-mesenchymal transformation in multiple types of cancer. In addition to its role in several types of neoplasias, miR-30b has been shown to exhibit essential roles in cardiovascular and metabolic diseases. In the present review, an overview of the biological functions of miR-30b and its role in the pathogenesis of neoplastic, cardiovascular and metabolic diseases is provided. miR-30b is a potential candidate for clinical development as a diagnostic and prognostic biomarker, therapeutic agent and drug target. However, further research is required to elucidate its role in health and disease and to harness its potential clinical utility.
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