期刊
CELL DEATH & DISEASE
卷 12, 期 1, 页码 -出版社
SPRINGERNATURE
DOI: 10.1038/s41419-020-03334-8
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类别
资金
- Medical and Health Technology Projects in Zhejiang, China [2020KY1052]
- National Natural Science Foundation of China [81472242, 81570549]
The research identified hsa_circ_0007456 as a promising biomarker for HCC, with its downregulation affecting the susceptibility of HCC cells to NK cells. Through modulation of the miR-6852-3p/ICAM-1 axis, hsa_circ_0007456 plays a crucial role in NK cell cytotoxicity towards HCC cells.
Circular RNAs (circRNAs) is one type of important non-coding RNAs that participate in tumorigenesis and cancer progression. In our previous study, we performed a microarray analysis of circRNAs between the tumor tissues and the adjacent normal tissues of hepatocellular carcinoma (HCC) patients, and found that the circRNA hsa_circ_0007456 is significantly downregulated in the tumor tissues and correlated with the prognosis of HCC. We further investigated the relationship between the expression levels of hsa_circ_0007456 in HCC and the susceptibility of NK cells, and found that the expression levels of hsa_circ_0007456 in HCC cell lines significantly influenced their susceptibility to NK cells. Through a series of screening and validation, we found that hsa_circ_0007456 mainly functioned through sponging miR-6852-3p and regulating the expression of intercellular adhesion molecule-1 (ICAM-1) in HCC. The miR-6852-3p/ICAM-1 axis is essential for the NK cytotoxicity toward HCC mediated by hsa_circ_0007456. In conclusion, we identify here hsa_circ_0007456 as a promising biomarker of HCC, and highlight hsa_circ_0007456/miR-6852-3p/ICAM-1 axis as an important signaling pathway in the process of tumor immune evasion and the tumorigenesis of HCC.
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