4.7 Article

Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Biochemistry & Molecular Biology

Modeling different types of diabetes using human pluripotent stem cells

Essam M. Abdelalim

Summary: Diabetes mellitus is a metabolic disease characterized by chronic hyperglycemia due to the progressive loss of pancreatic beta cells, leading to debilitating complications. Human pluripotent stem cell technology can generate in vitro human disease models, providing key insights into disease pathogenesis and personalized therapies. The development of functional beta cells from hPSCs, along with advancements in genomic and genome-editing technologies, offer multiple options to understand the cellular and molecular mechanisms underlying different types of diabetes.

CELLULAR AND MOLECULAR LIFE SCIENCES (2021)

Review Biochemistry & Molecular Biology

From Biology to Genes and Back Again: Gene Discovery for Monogenic Forms of Beta-Cell Dysfunction in Diabetes

Elisa De Franco

JOURNAL OF MOLECULAR BIOLOGY (2020)

Article Genetics & Heredity

Haploinsufficiency of the FOXA2 associated with a complex clinical phenotype

Idris Mohammed et al.

MOLECULAR GENETICS & GENOMIC MEDICINE (2020)

Article Endocrinology & Metabolism

Exome sequencing identifies a de novo FOXA2 variant in a patient with syndromic diabetes

Caroline Stekelenburg et al.

PEDIATRIC DIABETES (2019)

Article Biochemistry & Molecular Biology

Pre-marked chromatin and transcription factor co-binding shape the pioneering activity of Foxa2

Filippo M. Cernilogar et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Cell & Tissue Engineering

Dual Inhibition of BMP and WNT Signals Promotes Pancreatic Differentiation from Human Pluripotent Stem Cells

Mengtian Tan et al.

STEM CELLS INTERNATIONAL (2019)

Article Endocrinology & Metabolism

Congenital Hyperinsulinism and Hypopituitarism Attributable to a Mutation in FOXA2

Mary Ellen Vajravelu et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2018)

Article Cell & Tissue Engineering

Differentiation of human pluripotent stem cells into two distinct NKX6.1 populations of pancreatic progenitors

Idil I. Aigha et al.

STEM CELL RESEARCH & THERAPY (2018)

Article Cell & Tissue Engineering

Enhanced differentiation of human pluripotent stem cells into pancreatic progenitors co-expressing PDX1 and NKX6.1

Bushra Memon et al.

STEM CELL RESEARCH & THERAPY (2018)

Article Biochemistry & Molecular Biology

Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalities

Dinesh Giri et al.

HUMAN MOLECULAR GENETICS (2017)

Article Endocrinology & Metabolism

Foxa2 and Pdx1 cooperatively regulate postnatal maturation of pancreatic β-cells

Aimee Bastidas-Ponce et al.

MOLECULAR METABOLISM (2017)

Review Biochemistry & Molecular Biology

Notch Signaling in Pancreatic Development

Xu-Yan Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Article Developmental Biology

The global gene expression profile of the secondary transition during pancreatic development

Stefanie J. Willmann et al.

MECHANISMS OF DEVELOPMENT (2016)

Article Endocrinology & Metabolism

Foxa1 and Foxa2 Regulate α-Cell Differentiation, Glucagon Biosynthesis, and Secretion

Mounia Heddad Masson et al.

ENDOCRINOLOGY (2014)

Article Biotechnology & Applied Microbiology

Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells

Alireza Rezania et al.

NATURE BIOTECHNOLOGY (2014)

Article Developmental Biology

Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells

Solomon Afelik et al.

DEVELOPMENT (2012)

Review Anatomy & Morphology

Pancreas Organogenesis: From Bud to Plexus to Gland

Fong Cheng Pan et al.

DEVELOPMENTAL DYNAMICS (2011)

Article Endocrinology & Metabolism

HNF1A mutation presenting with fetal macrosomia and hypoglycemia in childhood prior to onset of overt diabetes

Petra Dusatkova et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2011)

Article Endocrinology & Metabolism

Foxa1 and Foxa2 Maintain the Metabolic and Secretory Features of the Mature β-Cell

Nan Gao et al.

MOLECULAR ENDOCRINOLOGY (2010)

Review Endocrinology & Metabolism

Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes

Rinki Murphy et al.

NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM (2008)

Article Biochemistry & Molecular Biology

Pax-6 and c-Maf functionally interact with the α-cell-specific DNA element G1 in vivo to promote glucagon gene expression

Yvan Gosmain et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Review Biochemistry & Molecular Biology

The Foxa family of transcription factors in development and metabolism

J. R. Friedman et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2006)

Article Endocrinology & Metabolism

Foxa2 controls Pdx1 gene expression in pancreatic β-cells in vivo

CS Lee et al.

DIABETES (2002)

Article Biochemistry & Molecular Biology

Foxa2 (HNF3β) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release

HY Wang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2002)

Article Medicine, Research & Experimental

Dominantly inherited hyperinsulinism caused by a mutation in the sulfonylurea receptor type 1

H Huopio et al.

JOURNAL OF CLINICAL INVESTIGATION (2000)

Article Developmental Biology

Notch gene expression during pancreatic organogenesis

E Lammert et al.

MECHANISMS OF DEVELOPMENT (2000)