期刊
JOURNAL OF MOLECULAR CELL BIOLOGY
卷 13, 期 3, 页码 161-167出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjaa064
关键词
COVID-19; cardiovascular diseases; SARS-CoV-2; ACE2; systemic inflammation
类别
资金
- National Key Research and Development Program of China [2018YFA0800200, 2018YFA0801200]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16010207]
- National Natural Science Foundation of China [31830061, 31425016, 81530004]
- State Key Laboratory of Membrane Biology of China
COVID-19, caused by SARS-CoV-2, not only affects the lungs but also has severe implications in the cardiovascular system. Understanding the mechanisms of cardiovascular injury in COVID-19 patients is crucial for appropriate identification and treatment.
The coronavirus disease 2019 (COVID-19) remains a global public health emergency. Despite being caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), besides the lung, this infectious disease also has severe implications in the cardiovascular system. In this review, we summarize diverse clinical complications of the heart and vascular system, as well as the relevant high mortality, in COVID-19 patients. Systemic inflammation and angiotensin-converting enzyme 2-involved signaling networking in SARS-CoV-2 infection and the cardiovascular system may contribute to the manifestations of cardiovascular diseases. Therefore, integration of clinical observations and experimental findings can promote our understanding of the underlying mechanisms, which would aid in identifying and treating cardiovascular injury in patients with COVID-19 appropriately.
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