期刊
JOURNAL OF MOLECULAR CELL BIOLOGY
卷 13, 期 2, 页码 79-90出版社
OXFORD UNIV PRESS
DOI: 10.1093/jmcb/mjaa080
关键词
Kruppel-like factor 5 (KLF5); vascular remodeling; inflammation; angiogenesis; drug development; microRNA
类别
资金
- National Natural Science Foundation of China [81970360]
This review summarizes the function and regulation mechanism network of KLF5 in vascular remodeling, highlighting its roles in cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis. The review also emphasizes the potential therapeutic applications of KLF5 in treating vascular disorders.
Vascular remodeling is a pathological basis of various disorders. Therefore, it is necessary to understand the occurrence, prevention, and treatment of vascular remodeling. Kruppel-like factor 5 (KLF5) has been identified as a significant factor in cardiovascular diseases during the last two decades. This review provides a mechanism network of function and regulation of KLF5 in vascular remodeling based on newly published data and gives a summary of its potential therapeutic applications. KLF5 modulates numerous biological processes, which play essential parts in the development of vascular remodeling, such as cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis by altering downstream genes and signaling pathways. Considering its essential functions, KLF5 could be developed as a potent therapeutic target in vascular disorders.
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