4.6 Review Book Chapter

Physiologically Based Modeling of Food Digestion and Intestinal Microbiota: State of the Art and Future Challenges. An INFOGEST Review

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ANNUAL REVIEWS
DOI: 10.1146/annurev-food-070620-124140

关键词

in silico; gastrointestinal tract; digestion; transit; absorption; microbiota

资金

  1. INFOGEST COST Action [FA1005]
  2. INRAE

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This review discusses the modeling methodologies of the gastrointestinal tract during digestion that adopt a systems-view approach, focusing on compartmental models of food digestion and host-diet-microbiota interactions. The review suggests that these models hold promise for understanding complex mechanisms of digestion, interpreting postprandial data, making predictions, and designing healthier foods in the future.
This review focuses on modeling methodologies of the gastrointestinal tract during digestion that have adopted a systems-view approach and, more particularly, on physiologically based compartmental models of food digestion and host-diet-microbiota interactions. This type of modeling appears very promising for integrating the complex stream of mechanisms that must be considered and retrieving a full picture of the digestion process from mouth to colon. We may expect these approaches to become more and more accurate in the future and to serve as a useful means of understanding the physicochemical processes occurring in the gastrointestinal tract, interpreting postprandial in vivo data, making relevant predictions, and designing healthier foods. This review intends to provide a scientific and historical background of this field of research, before discussing the future challenges and potential benefits of the establishment of such a model to study and predict food digestion and absorption in humans.

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