期刊
JOURNAL OF FUNCTIONAL FOODS
卷 76, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104288
关键词
Polyphenol extracts; Red raspberry; Seed; Pulp; Gut microbiota; Urolithins
资金
- USDA-NIFA [2017-67017-26781]
- University of Nebraska-Lincoln (UNL) Jumpstart Seed Grant
- UNL Quantitative Life Sciences Initiative
- Nebraska Research Initiative
Polyphenol extracts from red raspberry whole fruit or pulp, but not seed, can attenuate high-fat diet induced obesity in mice. These polyphenols have significant effects on the microbiota, decreasing specific taxa abundance and increasing beneficial Roseburia. Changes in the microbiome are closely correlated with improvements in host metabolic markers.
Polyphenol extracts from red raspberry (RR) whole fruit or pulp, but not seed, attenuate high-fat (HF) diet induced obesity in mice. Because host metabolism is linked to the microbiota, we investigated the effects of polyphenols from RR fruit, pulp, and seed on the microbiome. RR polyphenols significantly decreased the abundance of specific taxa that were increased during HF feeding relative to a low-fat diet, including Ruminococcus and an unclassified genus from Clostridiales. Compared to a HF diet, pulp and seed polyphenols increased Roseburia abundance and decreased levels of an unclassified genus from Mogibacteriaceae. RR seed polyphenols uniquely increased Bifidobacterium compared to a HF diet. The most notable taxon driving differential abundance among all diets was an unclassified genus from Coriobacteriaceae. Importantly, host metabolic markers improved by pulp polyphenols were strongly correlated with select microbiome features, indicating that specific gut bacteria may be involved in RR polyphenol catabolism and/or mediating health benefits.
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