期刊
JOURNAL OF FUNCTIONAL FOODS
卷 75, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104213
关键词
Rutaceae; Citrus; Limonoid; Chemical structure; Bioactivity; Anti-tumor
资金
- National Natural Science Foundation of China [81773975]
- Natural Science Foundation of Liaoning Province of China [20170540201, 2020-MZLH08]
- Foundation of Liaoning Educational Committee [LJYT201909]
- Opening Project of Zhejiang Provincial Preponderant and Characteristic Subject of Key University (Traditional Chinese Pharmacology), Zhejiang Chinese Medical University [ZYAOXYB2019011]
Citrus limonoids are tetranortriterpenoids compounds mainly found in oranges, lemons, grapefruits, and other fruits of Citrus. They are proved to be the leading cause of bitterness in Citrus fruits and are mainly consumed for therapeutic purposes and as food. Numerous studies have focused on Citrus limonoids and intend to develop new chemotherapeutic or complementary medicine in recent years. Citrus limonoids showed various bioactivities such as anti-tumor, antioxidative, anti-inflammatory, anti-neurological diseases, immunomodulatory, anti -insect, anti-bacteria, antiviral activities, etc. This review summarized limonoids from Citrus to date, along with their chemical structures and biological activities with a particular focus on their anti-tumor potential.
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