期刊
JOURNAL OF FUNCTIONAL FOODS
卷 75, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jff.2020.104234
关键词
Acrolein; Morin; Apoptotic markers; Proinflammatory cytokines; Signaling pathway
资金
- Department of Science and Technology of Guangdong Province [2019A1515110264]
- National Natural Science Foundation of China [31871902, 31972180]
Liver is the organ most frequently exposed to acrolein, a priority toxic pollutant. In the present study, whether morin can mitigate acrolein-induced cell damage in normal human hepatocyte cell line LO2 was investigated. Morin remarkably inhibited acrolein-induced apoptosis by inhibiting the expression of apoptotic markers, reducing the formation of proinflammatory cytokines, and blocking the ERK/JNK/P38-MAPK signaling pathway. The addition of equimolar morin decreased acrolein-induced cell apoptosis by 52.4%. The expression levels of apoptotic markers, BAX, Cyto-C, AIF, cleaved caspase-3/9, and PARP, decreased by 16%, 14%, 44%, 56%, 23%, and 45%, respectively. The proinflammatory cytokines, such as tumor necrosis factor alpha, inducible NO synthase, cyclooxygenase-2, interleukin 1 beta, and IFN-Upsilon were reduced by 39%, 55%, 66%, 72%, and 64%, respectively. The phosphorylation level of ERK1/2, JNK, and P38 MAPK decreased by 10%, 47%, and 26%, respectively. The present findings may provide a way to mitigate acrolein-induced hepatic injury.
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