New geographical area on the map of Crimean-Congo hemorrhagic fever virus: First serological evidence in the Hungarian population

Crimean-Congo hemorrhagic fever (CCHF) is an emerging tick-borne disease that is endemic in Africa, Asia, the Middle East, and the Balkan region of Europe; the disease is spreading northwards following widespread distribution of the main vector, Hyalomma marginatum, which was first found in Hungary in 2011. The aim of this pilot sero-surveillance study was to assess CCHF seroprevalence in Hungary. A total of 2700 serum samples obtained from healthy volunteer blood donors were screened using an in-house immunofluorescence assay and a commercially available ELISA kit. We found ten (0.37 %) seropositive donors. The western and central regions proved to be the most affected areas, with a prevalence of 2.97 %. Higher positivity was found among male donors (0.55 %) and younger donors (18-34 years; 0.78 %). Based on these results, a more extended surveillance focusing on specific at-risk populations and animals is advised. The results should also raise the awareness of clinicians and other high-risk populations, such as foresters and hunters, about the emerging threat of CCHF in Hungary.

Automated summary

A pilot sero-surveillance study in Hungary found a 0.37% seroprevalence of Crimean-Congo hemorrhagic fever, with higher rates in western and central regions, male donors, and donors aged 18-34 years. The results suggest the need for extended surveillance targeting specific at-risk populations and animals, as well as raising awareness among clinicians and high-risk groups about the emerging threat of CCHF in Hungary.