期刊
VIRUSES-BASEL
卷 13, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v13010074
关键词
Enterovirus A; human; poliomyelitis; wastewater; molecular epidemiology; Arizona
类别
资金
- National Library of Medicine of the USA National Institutes of Health [U01LM013129]
- Chemical, Bioengineering, Environmental and Transport Systems (CBET) Division of the National Science Foundation [2028564]
- J.M. Kaplan Fund
- Arizona State University Foundation [30009070]
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [2028564] Funding Source: National Science Foundation
A genotype C1-like Enterovirus A71 variant was found in wastewater in a neighborhood in Tempe, Arizona, circulating for over two years without its sequence being documented. The study emphasizes the importance of wastewater-based epidemiology (WBE) as an early warning system for virus surveillance, especially in light of changes caused by the COVID-19 pandemic.
We describe the complete capsid of a genotype C1-like Enterovirus A71 variant recovered from wastewater in a neighborhood in the greater Tempe, Arizona area (Southwest United States) in May 2020 using a pan-enterovirus amplicon-based high-throughput sequencing strategy. The variant seems to have been circulating for over two years, but its sequence has not been documented in that period. As the SARS-CoV-2 pandemic has resulted in changes in health-seeking behavior and overwhelmed pathogen diagnostics, our findings highlight the importance of wastewater-based epidemiology (WBE ) as an early warning system for virus surveillance.
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