期刊
VIRUSES-BASEL
卷 13, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v13010057
关键词
dengue virus type 1; phylogeny; phylogeography; origin; Senegal
类别
资金
- Brazilian National Council of Scientific and Technological Development (CNPq) [441105/2016-5]
- Sao Paulo Research Foundation (FAPESP) [2017/23281-6]
- FAPESP [2016/08204-2]
- Fiocruz/Pasteur/Aucani-FUSP [314502]
The outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was attributed to a single viral introduction from Asia. The virus appeared to have been introduced directly into Medina Gounass, Senegal around 2014 and subsequently spread to other regions within Senegal before moving to neighboring Mali.
Dengue virus (DENV) is the most widespread arthropod-borne virus, with the number and severity of outbreaks increasing worldwide in recent decades. Dengue is caused by genetically distinct serotypes, DENV-1-4. Here, we present data on DENV-1, isolated from patients with dengue fever during an outbreak in Senegal and Mali (Western Africa) in 2015-2019, that were analyzed by sequencing the envelope (E) gene. The emergence and the dynamics of DENV-1 in Western Africa were inferred by using maximum likelihood and Bayesian methods. The DENV-1 grouped into a monophyletic cluster that was closely related to those from Southeast Asia. The virus appears to have been introduced directly into Medina Gounass (Suburb of Dakar), Senegal (location probability = 0.301, posterior = 0.76). The introduction of the virus in Senegal occurred around 2014 (95% HPD = 2012.88-2014.84), and subsequently, the virus moved to regions within Senegal (e.g., Louga and Fatick), causing intense outbreaks in the subsequent years. The virus appears to have been introduced in Mali (a neighboring country) after its introduction in Senegal. In conclusion, we present evidence that the outbreak caused by DENV-1 in urban environments in Senegal and Mali after 2015 was caused by a single viral introduction from Asia.
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