期刊
VIRUSES-BASEL
卷 12, 期 11, 页码 -出版社
MDPI
DOI: 10.3390/v12111328
关键词
rhinovirus; epithelial cell; asthma; chemokines; metabolism; barrier function; airway remodeling
类别
资金
- Asthma Canada
- Canadian Allergy, Asthma, and Immunology Foundation (CAAIF)
- Lung Association, Alberta NWT
- Natural Science and Engineering Research Council of Canada (NSERC)
- Tier 1 Canada Research Chair in Inflammatory Airway Diseases
- Canadian Institutes of Health Research (CIHR) [PJT-159635]
- NSERC [RGPIN-2018-03861]
Human rhinoviruses have been linked both to the susceptibility of asthma development and to the triggering of acute exacerbations. Given that the human airway epithelial cell is the primary site of human rhinovirus (HRV) infection and replication, the current review focuses on how HRV-induced modulation of several aspects of epithelial cell phenotype could contribute to the development of asthma or to the induction of exacerbations. Modification of epithelial proinflammatory and antiviral responses are considered, as are alterations in an epithelial barrier function and cell phenotype. The contributions of the epithelium to airway remodeling and to the potential modulation of immune responses are also considered. The potential interactions of each type of HRV-induced epithelial phenotypic changes with allergic sensitization and allergic phenotype are also considered in the context of asthma development and of acute exacerbations.
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