期刊
出版社
WILEY
DOI: 10.1002/wnan.1685
关键词
artificial cells; in vitro reconstitution; protein compartment; synthetic cell
资金
- Alfred P. Sloan Foundation
- Gordon and Betty Moore Foundation [5506]
- National Institute of General Medical Sciences [R35GM119688, R35GM133325]
- National Science Foundation [1553031, 1817478, 1817909, 1844132, 1935265, 1939534, 1941966]
- Direct For Biological Sciences [1817909, 1553031, 1935265, 1817478] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1941966] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1939534] Funding Source: National Science Foundation
- Directorate For Engineering [1844132] Funding Source: National Science Foundation
- Div Of Chem, Bioeng, Env, & Transp Sys [1844132] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [1553031, 1817478, 1817909] Funding Source: National Science Foundation
- Emerging Frontiers [1935265] Funding Source: National Science Foundation
Constructing synthetic cells is a cutting-edge and challenging area of research. Two key features necessary for recreating cellular processes are compartmentalization and self-organization/spatiotemporal dynamics.
Constructing synthetic cells has recently become an appealing area of research. Decades of research in biochemistry and cell biology have amassed detailed part lists of components involved in various cellular processes. Nevertheless, recreating any cellular process in vitro in cell-sized compartments remains ambitious and challenging. Two broad features or principles are key to the development of synthetic cells-compartmentalization and self-organization/spatiotemporal dynamics. In this review article, we discuss the current state of the art and research trends in the engineering of synthetic cell membranes, development of internal compartmentalization, reconstitution of self-organizing dynamics, and integration of activities across scales of space and time. We also identify some research areas that could play a major role in advancing the impact and utility of engineered synthetic cells. This article is categorized under: Biology-Inspired Nanomaterials > Lipid-Based Structures Biology-Inspired Nanomaterials > Protein and Virus-Based Structures
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