期刊
VIROLOGY
卷 556, 期 -, 页码 96-100出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2021.01.005
关键词
SARS-CoV-2; COVID-19; Severe acute respiratory syndrome; Coronavirus; Hamster model; Syrian hamsters; Spike protein
类别
资金
- internal US FDA
By infecting hamsters with two variants of SARS-CoV-2, this study found that there was no significant difference in pathogenicity between the naturally circulating D614 and G614 variants.
Dynamic tracking of variant frequencies among viruses circulating in the global pandemic has revealed the emergence and dominance of a D614G mutation in the SARS-CoV-2 spike protein. To address whether pandemic SARS-CoV-2 G614 variant has evolved to become more pathogenic, we infected adult hamsters (>10 months old) with two natural SARS-CoV-2 variants carrying either D614 or G614 spike protein to mimic infection of the adult/elderly human population. Hamsters infected by the two variants exhibited comparable viral loads and pathology in lung tissues as well as similar amounts of virus shed in nasal washes. Altogether, our study does not find that naturally circulating D614 and G614 SARS-CoV-2 variants differ significantly in pathogenicity in hamsters.
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