期刊
ULTRAMICROSCOPY
卷 220, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ultramic.2020.113146
关键词
Autofocus; Whole slide imaging; Convolution neural network; Recurrent neural network
类别
资金
- Fundamental Research Funds of the Central Universities of Central South University [2019zzts597]
- National Natural Science Foundation of China [61602522, 62006249]
The proposed autofocus algorithm for whole slide imaging utilizes convolution and recurrent neural networks to predict the out-of-focus distance and update the focus location of the camera lens iteratively, achieving rapid determination of the optimal in-focus image.
During the process of whole slide imaging, it is necessary to focus thousands of fields of view to obtain a high-quality image. To make the focusing procedure efficient and effective, we propose a novel autofocus algorithm for whole slide imaging. It is based on convolution and recurrent neural networks to predict the out-of-focus distance and subsequently update the focus location of the camera lens in an iterative manner. More specifically, we train a convolution neural network to extract focus information in the form of a focus feature vector. In order to make the prediction more accurate, we apply a recurrent neural network to combine focus information from previous search iteration and current search iteration to form a feature aggregation vector. This vector contains more focus information than the previous one and is subsequently used to predict the out-of-focus distance. Our experiments indicate that our proposed autofocus algorithm is able to rapidly determine the optimal in-focus image.
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