期刊
TRENDS IN PARASITOLOGY
卷 37, 期 5, 页码 381-390出版社
CELL PRESS
DOI: 10.1016/j.pt.2020.12.006
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资金
- Human Frontier Science Program [RGP0062/2018]
This article discusses the behavioral manipulation mechanism of Toxoplasma gondii on intermediate hosts, proposing the role of gonadal steroids in this process. The presence of tissue cysts in the host brain is considered merely a side effect of behavioral change, rather than a necessary or sufficient factor.
The protozoan parasite Toxoplasma gondii infects a wide range of intermediate hosts. The parasite produces brain cysts during the latent phase of its infection, in parallel to causing a loss of innate aversion in the rat host towards cat odors. Host behavioral change presumably reflects a parasitic manipulation to increase predation by definitive felid hosts, although evidence for increased predation is not yet available. In this opinion piece, we propose a neuroendocrine loop to explain the role of gonadal steroids in the parasitized hosts in mediating the behavioral manipulation. We argue that the presence of tissue cysts within the host brain is merely incidental to the behavioral change, without a necessary or sufficient role.
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