期刊
TRENDS IN MICROBIOLOGY
卷 29, 期 5, 页码 388-393出版社
CELL PRESS
DOI: 10.1016/j.tim.2020.12.001
关键词
-
资金
- National Science Foundation of China [91951203, 31625001]
- National Key R&D Program of China [2018YFC1406500]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong laboratory (Guangzhou) [GML2019ZD0407]
- CAMS Initiative for Innovative Medicine [2016-I2M-1-013]
- Biotechnology Endowed Professorship at the Pennsylvania State University
This study identified three new TA systems where the antitoxin is an enzyme that chemically modifies the toxin to neutralize its activity. The suggestion to introduce the type VII TA system will help classify enzyme-antitoxin reaction-based TA systems.
Toxin/antitoxin (TA) systems are present in nearly all bacterial and archaeal strains and consist of a toxin that reduces growth and an antitoxin that masks toxin activity. Currently there are six primary classes for TA systems based on the nature of the antitoxin and the way that the antitoxin inactivates the toxin. Here we show that there now are at least three additional and distinct TA systems in which the antitoxin is an enzyme and the cognate toxin is the direct target of the antitoxin: Hha/TomB (antitoxin oxidizes Cys18 of the toxin), TglT/TakA (antitoxin phosphorylates Ser78 of the toxin), and HepT/MntA (antitoxin adds three AMPs to Tyr104 of the toxin). Thus, we suggest the type VII TA system should be used to designate those TA systems in which the enzyme antitoxin chemically modifies the toxin post-translationally to neutralize it. Defining the type VII TA system using this specific criterion will aid researchers in classifying newly discovered TA systems as well as refine the framework for recognizing the diverse biochemical functions in TA systems.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据