期刊
TRENDS IN IMMUNOLOGY
卷 42, 期 1, 页码 31-44出版社
CELL PRESS
DOI: 10.1016/j.it.2020.11.003
关键词
-
类别
资金
- Fondation pour la Recherche Medicale (FRM -Aide aux Equipes, France)
Most individuals infected with SARS-CoV-2 have mild symptoms, possibly due to their ability to rapidly produce interferons, while a minority of infected individuals with chronic inflammatory conditions lack this early efficient response.
The majority of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)infected individuals remain paucisymptomatic, contrasting with a minority of infected individuals in danger of death. Here, we speculate that the robust disease resistance of most individuals is due to a swift production of type I interferon (IFN alpha/beta), presumably sufficient to lower the viremia. A minority of infected individuals with a preexisting chronic inflammatory state fail to mount this early efficient response, leading to a delayed harmful inflammatory response. To improve the epidemiological scenario, we propose combining: (i) the development of efficient antivirals administered early enough to assist in the production of endogenous IFN alpha/beta; (ii) potentiating early IFN responses; (iii) administering anti-inflammatory treatments when needed, but not too early to interfere with endogenous antiviral responses.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据