期刊
TRENDS IN ENDOCRINOLOGY AND METABOLISM
卷 32, 期 3, 页码 159-169出版社
CELL PRESS
DOI: 10.1016/j.tem.2020.12.003
关键词
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资金
- National Natural Science Foundation of China [32072744, 31802068, 31790411]
- Key Research Program of Frontier Sciences, CAS [QYZDY-SSW-SMC008]
- Earmarked Fund of China Agriculture Research System [CARS-35]
- Natural Science Foundation of Guangdong Province [2018A030310145]
Butyrate, as a main product of gut microbial fermentation, plays an important role in regulating whole body energy homeostasis. Research has shown that butyrate has multiple effects on metabolic health, including thermogenesis, lipid and glucose metabolism, appetite, inflammation, and influence on gut microbiota. Through pathways such as G protein-coupled receptors (GPRs) and acting as a histone deacetylase inhibitor, butyrate also impacts cellular systems.
Butyrate, a main product of gut microbial fermentation, has been recognized as an important mediator of gut microbiota regulation in whole body energy homeostasis. However, the mechanisms of butyrate metabolic control remain unclear. This review summarizes studies that directly examined the effects of butyrate on metabolic health. The effects of butyrate on metabolic functions, including thermogenesis, lipid and glucose metabolism, appetite, inflammation, and influence on gut microbiota, are described. The effects of butyrate on cellular systems via G protein-coupled receptors (GPRs), as a histone deacetylase inhibitor, and as a substrate that is metabolized intercellularly, are also discussed. Hopefully, a better understanding of butyrate metabolic regulation may provide new perspectives for the nutritional prevention and treatment of metabolic diseases.
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